MTM1 antibody (AA 484-603)

Catalog No. ABIN7160627

This Rabbit Polyclonal antibody specifically detects MTM1 in WB, ELISA and IHC. It exhibits reactivity toward Human.

Quick Overview for MTM1 antibody (AA 484-603) (ABIN7160627)

Target: MTM1 (Myotubularin 1 (MTM1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MTM1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-MTM1 Antibody

Binding Specificity: AA 484-603

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Myotubularin protein (484-603AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:200-1:1000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for MTM1

Target: MTM1 (Myotubularin 1 (MTM1))

Alternative Name: MTM1

Background:

Background: Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides. Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome. Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture. Plays a role in mitochondrial morphology and positioning. Required for skeletal muscle maintenance but not for myogenesis.

Aliases: AF073996 antibody, CG2 antibody, CNM antibody, KIAA4176 antibody, mKIAA4176 antibody, Mtm antibody, Mtm1 antibody, MTM1_HUMAN antibody, MTMX antibody, Myotubular myopathy 1 antibody, Myotubularin antibody, XLMTM antibody

UniProt: Q13496

Pathways: Inositol Metabolic Process, Skeletal Muscle Fiber Development