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MTM1 antibody (N-Term)

MTM1 Reactivity: Human WB, IHC (p) Host: Rabbit Polyclonal RB0722 unconjugated
Catalog No. ABIN1882103
  • Target See all MTM1 Antibodies
    MTM1 (Myotubularin 1 (MTM1))
    Binding Specificity
    • 16
    • 10
    • 8
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-30, N-Term
    Reactivity
    • 43
    • 33
    • 19
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Host
    • 41
    • 3
    • 1
    Rabbit
    Clonality
    • 43
    • 2
    Polyclonal
    Conjugate
    • 20
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MTM1 antibody is un-conjugated
    Application
    • 45
    • 21
    • 14
    • 13
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Predicted Reactivity
    B
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This MTM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human MTM1.
    Clone
    RB0722
    Isotype
    Ig Fraction
    Top Product
    Discover our top product MTM1 Primary Antibody
  • Application Notes
    WB: 1:1000. IHC-P: 1:50~100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Expiry Date
    6 months
  • Jian, Cheng, Jiang, Deng, Hu, Zhang: "A cDNA-based random RNA interference library for functional genetic screens in embryonic stem cells." in: Stem cells (Dayton, Ohio), Vol. 25, Issue 8, pp. 1904-12, (2007) (PubMed).

    Nandurkar, Layton, Laporte, Selan, Corcoran, Caldwell, Mochizuki, Majerus, Mitchell: "Identification of myotubularin as the lipid phosphatase catalytic subunit associated with the 3-phosphatase adapter protein, 3-PAP." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 15, pp. 8660-5, (2003) (PubMed).

    Biancalana, Caron, Gallati, Baas, Kress, Novelli, DApice, Lagier-Tourenne, Buj-Bello, Romero, Mandel: "Characterisation of mutations in 77 patients with X-linked myotubular myopathy, including a family with a very mild phenotype." in: Human genetics, Vol. 112, Issue 2, pp. 135-42, (2003) (PubMed).

    Herman, Kopacz, Zhao, Mills, Metzenberg, Das: "Characterization of mutations in fifty North American patients with X-linked myotubular myopathy." in: Human mutation, Vol. 19, Issue 2, pp. 114-21, (2002) (PubMed).

    Wishart, Dixon: "PTEN and myotubularin phosphatases: from 3-phosphoinositide dephosphorylation to disease." in: Trends in cell biology, Vol. 12, Issue 12, pp. 579-85, (2002) (PubMed).

    Sutton, Winer, Norman, Liechti-Gallati, MacDonald: "Limb girdle and facial weakness in female carriers of X-linked myotubular myopathy mutations." in: Neurology, Vol. 57, Issue 5, pp. 900-2, (2001) (PubMed).

  • Target
    MTM1 (Myotubularin 1 (MTM1))
    Alternative Name
    MTM1 (MTM1 Products)
    Synonyms
    CNM antibody, MTMX antibody, XLMTM antibody, wu:fb19c01 antibody, zgc:123266 antibody, myotubularin 1 antibody, myotubularin 1 S homeolog antibody, MTM1 antibody, mtm1 antibody, mtm1.S antibody, Mtm1 antibody
    Background
    MTM1 is a member of a protein family that encodes tyrosine phosphatases. Myotubularin is required for muscle cell differentiation and mutations in MTM1 have been identified as being responsible for X-linked myotubular myopathy. MTM1 is a potent phosphatidylinositol 3-phosphate phosphatase (PI(3)P). Mutations in the MTM1 gene that cause human myotubular myopathy dramatically reduce the ability of the phosphatase to dephosphorylate PI(3)P. The findings provided evidence that myotubularin exerts its effects during myogenesis by regulating the cellular levels of the inositol lipid PI(3)P.
    Molecular Weight
    69932
    NCBI Accession
    NP_000243
    UniProt
    Q13496
    Pathways
    Inositol Metabolic Process, Skeletal Muscle Fiber Development
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