SMYD2A antibody (AA 115-272)

Catalog No. ABIN7160774

This Rabbit Polyclonal antibody specifically detects SMYD2A in ELISA, IHC and IF. It exhibits reactivity toward Human.

Quick Overview for SMYD2A antibody (AA 115-272) (ABIN7160774)

Target: SMYD2A (SET and MYND Domain Containing 2a (SMYD2A))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SMYD2A antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-SMYD2A Antibody

Binding Specificity: AA 115-272

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human N-lysine methyltransferase SMYD2 protein (115-272AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for SMYD2A

Target: SMYD2A (SET and MYND Domain Containing 2a (SMYD2A))

Alternative Name: SMYD2

Background:

Background: Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically methylates histone H3 \\\'Lys-4\\\' (H3K4me) and dimethylates histone H3 \\\'Lys-36\\\' (H3K36me2). Shows even higher methyltransferase activity on p53/TP53. Monomethylates \\\'Lys-370\\\' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at \\\'Lys-860\\\'.

Aliases: Histone methyltransferase SMYD2 antibody, HSKM B antibody, HSKM-B antibody, HSKMB antibody, KMT3C antibody, Lysine N-methyltransferase 3C antibody, MGC119305 antibody, N lysine methyltransferase SMYD2 antibody, N-lysine methyltransferase SMYD2 antibody, SET and MYND domain containing 2 antibody, SET and MYND domain containing protein 2 antibody, SET and MYND domain-containing protein 2 antibody, Smyd2 antibody, SMYD2_HUMAN antibody, Zinc finger MYND domain containing 14 antibody, ZMYND14 antibody

UniProt: Q9NRG4