SIRT6 antibody (AA 1-355)

Catalog No. ABIN7160865

The Rabbit Polyclonal anti-SIRT6 antibody has been validated for ELISA. It is suitable to detect SIRT6 in samples from Human.

Quick Overview for SIRT6 antibody (AA 1-355) (ABIN7160865)

Target: SIRT6 (Sirtuin 6 (SIRT6))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SIRT6 antibody is un-conjugated

Application: ELISA

Product Details anti-SIRT6 Antibody

Binding Specificity: AA 1-355

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human NAD-dependent protein deacetylase sirtuin-6 protein (1-355AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for SIRT6

Target: SIRT6 (Sirtuin 6 (SIRT6))

Alternative Name: SIRT6

Background:

Background: NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD+ in the absence of acetylated substrate.

Aliases: 2810449N18Rik antibody, AI043036 antibody, Mono ADP ribosyltransferase sirtuin 6 antibody, NAD-dependent protein deacetylase sirtuin-6 antibody, Regulatory protein SIR2 homolog 6 antibody, Regulatory protein SIR2 homolog antibody, SIR2 like 6 antibody, SIR2 like protein 6 antibody, Sir2 related protein type 6 antibody, SIR2-like protein 6 antibody, SIR2L6 antibody, SIR6_HUMAN antibody, SIRT 6 antibody, SIRT6 antibody, Sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae) antibody, Sirtuin 6 antibody, Sirtuin type 6 antibody, Sirtuin6 antibody

UniProt: Q8N6T7