COBRA1 antibody (AA 8-199) (Biotin)

Catalog No. ABIN7161140

This Rabbit Polyclonal antibody specifically detects COBRA1 in ELISA. It exhibits reactivity toward Human.

Quick Overview for COBRA1 antibody (AA 8-199) (Biotin) (ABIN7161140)

Target: COBRA1 (Cofactor of BRCA1 (COBRA1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COBRA1 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-COBRA1 Antibody (Biotin)

Binding Specificity: AA 8-199

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Negative elongation factor B protein (8-199AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for COBRA1

Target: COBRA1 (Cofactor of BRCA1 (COBRA1))

Alternative Name: NELFB

Background:

Background: Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. Binds RNA which may help to stabilize the NELF complex on nucleic acid. In vitro, binds weakly to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1. May be able to induce chromatin unfolding.

Aliases: NELFB antibody, COBRA1 antibody, KIAA1182 antibody, Negative elongation factor B antibody, NELF-B antibody, Cofactor of BRCA1 antibody

UniProt: Q8WX92