NOTCH2 antibody (AA 59-250) (Biotin)

Catalog No. ABIN7161299

This Rabbit Polyclonal antibody specifically detects NOTCH2 in ELISA. It exhibits reactivity toward Human.

Quick Overview for NOTCH2 antibody (AA 59-250) (Biotin) (ABIN7161299)

Target: NOTCH2 (Notch 2 (NOTCH2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NOTCH2 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-NOTCH2 Antibody (Biotin)

Binding Specificity: AA 59-250

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Neurogenic locus notch homolog protein 2 protein (59-250AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for NOTCH2

Target: NOTCH2 (Notch 2 (NOTCH2))

Alternative Name: NOTCH2

Background:

Background: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. Positively regulates self-renewal of liver cancer cells (PubMed:25985737).

Aliases: AGS2 antibody, hN2 antibody, Motch B antibody, N2 antibody, N2ECD antibody, N2ICD antibody, neurogenic locus notch homolog protein 2 antibody, NOTC2_HUMAN antibody, Notch 2 antibody, Notch 2 intracellular domain antibody, Notch Drosophila homolog 2 antibody, Notch homolog 2 antibody, Notch homolog 2 Drosophila antibody, Notch2 antibody

UniProt: Q04721

Pathways: Notch Signaling, Stem Cell Maintenance