NrCAM antibody (AA 1194-1299)

Catalog No. ABIN7161362

This Rabbit Polyclonal antibody specifically detects NrCAM in ELISA, IHC and IF. It exhibits reactivity toward Human.

Quick Overview for NrCAM antibody (AA 1194-1299) (ABIN7161362)

Target: NrCAM (NRCAM) (Neuronal Cell Adhesion Molecule (NRCAM))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NrCAM antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-NrCAM Antibody

Binding Specificity: AA 1194-1299

Purpose: NRCAM Antibody

Purification: Protein G purified

Purity: >95 %

Immunogen: Recombinant Human Neuronal cell adhesion molecule protein (1194-1299AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for NrCAM

Target: NrCAM (NRCAM) (Neuronal Cell Adhesion Molecule (NRCAM))

Alternative Name: NRCAM

Background:

Background: Cell adhesion protein that is required for normal responses to cell-cell contacts in brain and in the peripheral nervous system. Plays a role in neurite outgrowth in response to contactin binding. Plays a role in mediating cell-cell contacts between Schwann cells and axons. Plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes, not required for the formation of mature nodes with normal sodium channel clusters. Required, together with GLDN, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier.

Aliases: Bravo antibody, hBravo antibody, Neuronal cell adhesion molecule antibody, Neuronal surface protein Bravo antibody, Ng CAM related antibody, Ng-CAM-related antibody, NgCAM related cell adhesion molecule antibody, NgCAM-related cell adhesion molecule antibody, Nr CAM antibody, Nr-CAM antibody, Nrcam antibody, NRCAM_HUMAN antibody

UniProt: Q92823

Pathways: Regulation of Cell Size