NPRL2 antibody (AA 1-220)

Catalog No. ABIN7161635

This Rabbit Polyclonal antibody specifically detects NPRL2 in WB, ELISA and IHC. It exhibits reactivity toward Human.

Quick Overview for NPRL2 antibody (AA 1-220) (ABIN7161635)

Target: NPRL2 (Nitrogen Permease Regulator-Like 2 (S. Cerevisiae) (NPRL2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NPRL2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-NPRL2 Antibody

Binding Specificity: AA 1-220

Cross-Reactivity: Human, Mouse

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Nitrogen permease regulator 2-like protein (1-220AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for NPRL2

Target: NPRL2 (Nitrogen Permease Regulator-Like 2 (S. Cerevisiae) (NPRL2))

Alternative Name: NPRL2

Background:

Background: Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at \\\'Tyr-9\\\', \\\'Tyr-373\\\' and \\\'Tyr-376\\\' residues. May act as a tumor suppressor. Suppresses cell growth and enhances sensitivity to various anticancer drugs. As a component of the GATOR1 complex, inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling.

Aliases: 2810446G01Rik antibody, G21 protein antibody, Gene 21 protein antibody, Homologous to yeast nitrogen permease (candidate tumor suppressor) antibody, Homologous to yeast nitrogen permease antibody, Nitrogen permease regulator 2-like protein antibody, Nitrogen permease regulator-like 2 (S. cerevisiae) antibody, NPR 2L antibody, NPR L2 antibody, NPR like 2 antibody, NPR2 antibody, NPR2 like antibody, NPR2-like protein antibody, NPR2L antibody, NPRL 2 antibody, NPRL2 antibody, NPRL2_HUMAN antibody, Tumor suppressor candidate 4 antibody, TUSC 4 antibody, TUSC 4 protein antibody, TUSC4 antibody, TUSC4 protein antibody

UniProt: Q8WTW4