NDEL1 antibody (AA 1-345)

Catalog No. ABIN7161756

The Rabbit Polyclonal anti-NDEL1 antibody has been validated for ELISA. It is suitable to detect NDEL1 in samples from Human.

Quick Overview for NDEL1 antibody (AA 1-345) (ABIN7161756)

Target: NDEL1 (NudE Nuclear Distribution E Homolog (A. Nidulans)-Like 1 (NDEL1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NDEL1 antibody is un-conjugated

Application: ELISA

Product Details anti-NDEL1 Antibody

Binding Specificity: AA 1-345

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Nuclear distribution protein nudE-like 1 protein (1-345AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for NDEL1

Target: NDEL1 (NudE Nuclear Distribution E Homolog (A. Nidulans)-Like 1 (NDEL1))

Alternative Name: NDEL1

Background:

Background: Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL.

Aliases: A. nidulans antibody, DKFZp451M0318 antibody, ENDOOLIGOPEPTIDASE A antibody, EOPA antibody, MITAP 1 antibody, MITAP1 antibody, Mitosin associated protein 1 antibody, Mitosin associated protein MITAP1 antibody, Mitosin-associated protein 1 antibody, Ndel 1 antibody, NDEL1 antibody, NDEL1_HUMAN antibody, Nuclear distribution gene E like homolog 1 antibody, Nuclear distribution protein nudE like 1 antibody, Nuclear distribution protein nudE-like 1 antibody, NUDE like protein antibody, NudE nuclear distribution gene E homolog like 1 A. nidulans antibody, NudE nuclear distribution gene E homolog like 1 antibody, NUDEL antibody, Protein Nudel antibody

UniProt: Q9GZM8

Pathways: Regulation of Cell Size