NR2C1 antibody (AA 1-240)

Catalog No. ABIN7161903

The Rabbit Polyclonal anti-NR2C1 antibody is suitable to detect NR2C1 in samples from Human. It has been validated for WB, ELISA and IHC.

Quick Overview for NR2C1 antibody (AA 1-240) (ABIN7161903)

Target: NR2C1 (Nuclear Receptor Subfamily 2, Group C, Member 1 (NR2C1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NR2C1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-NR2C1 Antibody

Binding Specificity: AA 1-240

Purpose: NR2C1 Antibody

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Nuclear receptor subfamily 2 group C member 1 protein (1-240AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for NR2C1

Target: NR2C1 (Nuclear Receptor Subfamily 2, Group C, Member 1 (NR2C1))

Alternative Name: NR2C1

Background:

Background: Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5\\\'-AGGTCA-3\\\' half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiation. Mediator of retinoic acid-regulated preadipocyte proliferation.

Aliases: NR2C1 antibody, TR2 antibody, Nuclear receptor subfamily 2 group C member 1 antibody, Orphan nuclear receptor TR2 antibody, Testicular receptor 2 antibody

UniProt: P13056

Pathways: Nuclear Receptor Transcription Pathway, Retinoic Acid Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway