ZC3HC1 antibody (AA 1-260)

Catalog No. ABIN7161952

This anti-ZC3HC1 antibody is a Rabbit Polyclonal antibody detecting ZC3HC1 in WB, ELISA and IHC. Suitable for Human.

Quick Overview for ZC3HC1 antibody (AA 1-260) (ABIN7161952)

Target: ZC3HC1 (Zinc Finger, C3HC-Type Containing 1 (ZC3HC1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZC3HC1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-ZC3HC1 Antibody

Binding Specificity: AA 1-260

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Nuclear-interacting partner of ALK protein (1-260AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for ZC3HC1

Target: ZC3HC1 (Zinc Finger, C3HC-Type Containing 1 (ZC3HC1))

Alternative Name: ZC3HC1

Background:

Background: Essential component of an SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events.

Aliases: hNIPA antibody, NIPA_HUMAN antibody, Nuclear interacting partner of ALK antibody, Nuclear interacting partner of anaplastic lymphoma kinase antibody, Nuclear-interacting partner of ALK antibody, Nuclear-interacting partner of anaplastic lymphoma kinase antibody, zc3hc1 antibody, Zinc finger C3HC type containing 1 antibody, Zinc finger C3HC-type protein 1 antibody

UniProt: Q86WB0