ZC3HC1 antibody (C-Term)
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- Target See all ZC3HC1 Antibodies
- ZC3HC1 (Zinc Finger, C3HC-Type Containing 1 (ZC3HC1))
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Binding Specificity
- C-Term
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This ZC3HC1 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
- Specificity
- NIPA Antibody detects endogenous levels of total NIPA.
- Predicted Reactivity
- Pig,Bovine,Horse,Sheep,Rabbit,Dog
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human NIPA, corresponding to a region within C-terminal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product ZC3HC1 Primary Antibody
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- Application Notes
- WB 1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20 °C. Stable for 12 months from date of receipt.
- Expiry Date
- 12 months
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- Target
- ZC3HC1 (Zinc Finger, C3HC-Type Containing 1 (ZC3HC1))
- Alternative Name
- ZC3HC1 (ZC3HC1 Products)
- Synonyms
- 1110054L24Rik antibody, AU018540 antibody, AU019789 antibody, HSPC216 antibody, Nipa antibody, NIPA antibody, RGD1561099 antibody, zinc finger, C3HC type 1 antibody, zinc finger C3HC-type containing 1 antibody, zinc finger, C3HC-type containing 1 antibody, Zc3hc1 antibody, ZC3HC1 antibody
- Background
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Description: Essential component of a SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events.
Gene: ZC3HC1
- Molecular Weight
- 55kDa
- Gene ID
- 51530
- UniProt
- Q86WB0
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