MACROD1 antibody (AA 83-325) (HRP)

Catalog No. ABIN7162106

This Rabbit Polyclonal antibody specifically detects MACROD1 in ELISA. It exhibits reactivity toward Human.

Quick Overview for MACROD1 antibody (AA 83-325) (HRP) (ABIN7162106)

Target: MACROD1 (MACRO Domain Containing 1 (MACROD1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MACROD1 antibody is conjugated to HRP

Application: ELISA

Product Details anti-MACROD1 Antibody (HRP)

Binding Specificity: AA 83-325

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human O-acetyl-ADP-ribose deacetylase MACROD1 protein (83-325AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for MACROD1

Target: MACROD1 (MACRO Domain Containing 1 (MACROD1))

Alternative Name: MACROD1

Background:

Background: Removes ADP-ribose from glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Plays a role in estrogen signaling. Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen. May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation. Could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction. Could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells. Enhances ESR1-mediated transcription activity.

Aliases: MACROD1 antibody, LRP16 antibody, ADP-ribose glycohydrolase MACROD1 antibody, MACRO domain-containing protein 1 antibody, O-acetyl-ADP-ribose deacetylase MACROD1 antibody, EC 3.1.1.106 antibody, Protein LRP16 antibody, [Protein ADP-ribosylaspartate] hydrolase MACROD1 antibody, EC 3.2.2.- antibody, [Protein ADP-ribosylglutamate] hydrolase MACROD1 antibody, EC 3.2.2.- antibody

UniProt: Q9BQ69