PPIF antibody (AA 30-207)

Catalog No. ABIN7162809

The Rabbit Polyclonal anti-PPIF antibody has been validated for WB, IHC and ELISA. It is suitable to detect PPIF in samples from Human.

Quick Overview for PPIF antibody (AA 30-207) (ABIN7162809)

Target: PPIF (Peptidylprolyl Isomerase F (PPIF))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PPIF antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-PPIF Antibody

Binding Specificity: AA 30-207

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Peptidyl-prolyl cis-trans isomerase F, mitochondrial protein (30-207AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PPIF

Target: PPIF (Peptidylprolyl Isomerase F (PPIF))

Alternative Name: PPIF

Background:

Background: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis, the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial TP53 is involved in activating oxidative stress-induced necrosis. Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis.

Aliases: Cyclophilin 3 antibody, cyclophilin D antibody, Cyclophilin F antibody, Cyp D antibody, CyP M antibody, CyP-D antibody, CyP-M antibody, CYP3 antibody, CypD antibody, hCyP3 antibody, mitochondrial antibody, Mitochondrial cyclophilin antibody, Peptidyl prolyl cis trans isomerase, mitochondral antibody, Peptidyl-prolyl cis-trans isomerase F antibody, Peptidyl-prolyl cis-trans isomerase F, mitochondrial antibody, Peptidylprolyl isomerase F (cyclophilin F) antibody, Peptidylprolyl isomerase F antibody, PPIase antibody, PPIase F antibody, Ppif antibody, PPIF_HUMAN antibody, Rotamase antibody, Rotamase F antibody

UniProt: P30405

Pathways: Proton Transport, Negative Regulation of intrinsic apoptotic Signaling, Negative Regulation of Transporter Activity