LCAT antibody (AA 25-433) (Biotin)

Catalog No. ABIN7163128

This anti-LCAT antibody is a Rabbit Polyclonal antibody detecting LCAT in ELISA. Suitable for Human.

Quick Overview for LCAT antibody (AA 25-433) (Biotin) (ABIN7163128)

Target: LCAT (Lecithin-Cholesterol Acyltransferase (LCAT))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LCAT antibody is conjugated to Biotin

Application: ELISA

Product Details anti-LCAT Antibody (Biotin)

Binding Specificity: AA 25-433

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Phosphatidylcholine-sterol acyltransferase protein (25-433AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for LCAT

Target: LCAT (Lecithin-Cholesterol Acyltransferase (LCAT))

Alternative Name: LCAT

Background:

Background: Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs). The cholesterol ester is then transported back to the liver. Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines. Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels. Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins. Required for remodeling high-density lipoprotein particles into their spherical forms.

Aliases: LCAT antibody, LCAT_HUMAN antibody, Lecithin cholesterol acyltransferase antibody, Lecithin-cholesterol acyltransferase antibody, Phosphatidylcholine sterol acyltransferase antibody, Phosphatidylcholine-sterol acyltransferase antibody, Phospholipid cholesterol acyltransferase antibody, Phospholipid-cholesterol acyltransferase antibody

UniProt: P04180

Pathways: Lipid Metabolism