PIK3R2 antibody (Regulatory Subunit beta) (Biotin)

Catalog No. ABIN7163168

This Rabbit Polyclonal antibody specifically detects PIK3R2 in ELISA. It exhibits reactivity toward Human.

Quick Overview for PIK3R2 antibody (Regulatory Subunit beta) (Biotin) (ABIN7163168)

Target: PIK3R2 (PI3K p85b) (Phosphoinositide 3 Kinase, p85 beta (PI3K p85b))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PIK3R2 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-PIK3R2 Antibody (Biotin)

Binding Specificity: AA 75-125, Regulatory Subunit beta

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Phosphatidylinositol 3-kinase regulatory subunit beta protein (75-125AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PIK3R2

Target: PIK3R2 (PI3K p85b) (Phosphoinositide 3 Kinase, p85 beta (PI3K p85b))

Alternative Name: PIK3R2

Background:

Background: Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy (PubMed:23604317). Promotes nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (By similarity).

Aliases: p85 antibody, p85 beta antibody, P85B antibody, P85B_HUMAN antibody, Phosphatidylinositol 3 kinase antibody, Phosphatidylinositol 3 kinase regulatory beta subunit antibody, Phosphatidylinositol 3 kinase regulatory subunit beta antibody, Phosphatidylinositol 3 kinase regulatory subunit polypeptide 2 antibody, Phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 2 (p85 beta) antibody, Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta antibody, Phosphatidylinositol 3-kinase regulatory subunit beta antibody, Phosphoinositide 3 kinase regulatory subunit 2 (beta) antibody, Phosphoinositide 3 kinase regulatory subunit 2 antibody, Phosphoinositide 3 kinase regulatory subunit polypeptide 2 (p85 beta) antibody, Phosphoinositide 3 kinase regulatory subunit polypeptide 2 antibody, Phosphoinositide 3 kinase, regulatory subunit 2 (beta) antibody, Phosphoinositide 3 kinase, regulatory subunit 2 (p85 beta) antibody, PI3 kinase p85 beta subunit antibody, PI3 kinase p85 subunit beta antibody, PI3-kinase regulatory subunit beta antibody, PI3-kinase subunit p85-beta antibody, PI3K antibody, PI3K regulatory subunit beta antibody, PIK3R 2 antibody, PIK3R2 antibody, PtdIns 3 kinase p85 beta antibody, PtdIns-3-kinase regulatory subunit beta antibody, PtdIns-3-kinase regulatory subunit p85-beta antibody

UniProt: O00459

Pathways: VEGF Signaling, BCR Signaling