ATP8A1 antibody (AA 448-545) (Biotin)

Catalog No. ABIN7163367

The Rabbit Polyclonal anti-ATP8A1 antibody has been validated for ELISA. It is suitable to detect ATP8A1 in samples from Human.

Quick Overview for ATP8A1 antibody (AA 448-545) (Biotin) (ABIN7163367)

Target: ATP8A1 (ATPase, Class I, Type 8A, Member 1 (ATP8A1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ATP8A1 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-ATP8A1 Antibody (Biotin)

Binding Specificity: AA 448-545

Purpose: ATP8A1 Antibody, Biotin conjugated

Purification: Protein G purified

Purity: >95 %

Immunogen: Recombinant Human Phospholipid-transporting ATPase IA protein (448-545AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for ATP8A1

Target: ATP8A1 (ATPase, Class I, Type 8A, Member 1 (ATP8A1))

Alternative Name: ATP8A1

Background:

Background: Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. In vitro, its ATPase activity is selectively and stereospecifically stimulated by phosphatidylserine (PS). The flippase complex ATP8A1:TMEM30A seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the plasma membrane. Acts as aminophospholipid translocase at the plasma membrane in neuronal cells.

Aliases: ATP8A1 antibody, ATPIAPhospholipid-transporting ATPase IA antibody, EC 7.6.2.1 antibody, ATPase class I type 8A member 1 antibody, Chromaffin granule ATPase II antibody, P4-ATPase flippase complex alpha subunit ATP8A1 antibody

UniProt: Q9Y2Q0