ATP8A1 antibody (Internal Region)

Catalog No. ABIN6260139

Product Details anti-ATP8A1 Antibody

Target: ATP8A1 (ATPase, Class I, Type 8A, Member 1 (ATP8A1))

Binding Specificity: Internal Region

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ATP8A1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Specificity: ATP8A1 Antibody detects endogenous levels of total ATP8A1.

Predicted Reactivity: Pig,Bovine,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human ATP8A1, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for ATP8A1

Target: ATP8A1 (ATPase, Class I, Type 8A, Member 1 (ATP8A1))

Alternative Name: ATP8A1 (ATP8A1 Products)

Synonyms: ATPASEII antibody, ATPIA antibody, ATPP2 antibody, AI481521 antibody, AI853962 antibody, APLT antibody, AW743152 antibody, AW822227 antibody, Atp3a2 antibody, B230107D19Rik antibody, ClassI antibody, mKIAA4233 antibody, ATPase phospholipid transporting 8A1 antibody, ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 antibody, Atp8a1 antibody, ATP8A1 antibody

Background:

Description: Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. In vitro, its ATPase activity is selectively and stereospecifically stimulated by phosphatidylserine (PS). The flippase complex ATP8A1:TMEM30A seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the plasma membrane. Acts as aminophospholipid translocase at the plasma membrane in neuronal cells.

Gene: ATP8A1

Molecular Weight: 120 kDa

Gene ID: 10396

UniProt: Q9Y2Q0