PAFAH1B1 antibody (AA 40-155) (HRP)

Catalog No. ABIN7163604

The Rabbit Polyclonal anti-PAFAH1B1 antibody is suitable to detect PAFAH1B1 in samples from Human. It has been validated for ELISA.

Quick Overview for PAFAH1B1 antibody (AA 40-155) (HRP) (ABIN7163604)

Target: PAFAH1B1 (Platelet-Activating Factor Acetylhydrolase 1b, Regulatory Subunit 1 (45kDa) (PAFAH1B1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PAFAH1B1 antibody is conjugated to HRP

Application: ELISA

Product Details anti-PAFAH1B1 Antibody (HRP)

Binding Specificity: AA 40-155

Purpose: PAFAH1B1 Antibody, HRP conjugated

Purification: Protein G purified

Purity: >95 %

Immunogen: Recombinant Human Platelet-activating factor acetylhydrolase IB subunit alpha protein (40-155AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PAFAH1B1

Target: PAFAH1B1 (Platelet-Activating Factor Acetylhydrolase 1b, Regulatory Subunit 1 (45kDa) (PAFAH1B1))

Alternative Name: PAFAH1B1

Background:

Background: Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet-activating factor (PAF) by removing the acetyl group at the SN-2 position (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing.

Aliases: LIS 1 antibody, LIS 2 antibody, LIS-1 antibody, LIS1 antibody, LIS1_HUMAN antibody, LIS2 antibody, Lissencephaly 1 protein antibody, Lissencephaly-1 protein antibody, MDCR antibody, MDS antibody, PAF acetylhydrolase 45 kDa subunit antibody, PAF AH 45 kDa subunit antibody, PAF AH alpha antibody, PAF-AH 45 kDa subunit antibody, PAF-AH alpha antibody, PAFAH alpha antibody, PAFAH antibody, PAFAH1B1 antibody, PAFAHA antibody, Platelet activating factor acetylhydrolase 1b regulatory subunit 1 antibody, Platelet activating factor acetylhydrolase isoform Ib alpha subunit antibody, Platelet-activating factor acetylhydrolase IB subunit alpha antibody

UniProt: P43034

Pathways: M Phase, Regulation of Cell Size