DDX5 antibody (AA 1-290)

Catalog No. ABIN7164363

The Rabbit Polyclonal anti-DDX5 antibody has been validated for WB, ELISA and IHC. It is suitable to detect DDX5 in samples from Human.

Quick Overview for DDX5 antibody (AA 1-290) (ABIN7164363)

Target: DDX5 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 5 (DDX5))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DDX5 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-DDX5 Antibody

Binding Specificity: AA 1-290

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Probable ATP-dependent RNA helicase DDX5 protein (1-290AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for DDX5

Target: DDX5 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 5 (DDX5))

Alternative Name: DDX5

Background:

Background: Involved in the alternative regulation of pre-mRNA splicing, its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation, the function is independent of the RNA helicase activity. Transcriptional coactivator for estrogen receptor ESR1 and androgen receptor AR. Increases ESR1 AF-1 domain-mediated transactivation and ESR1 AF-1 and AF-2 domains transcriptional synergistic activity. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as transcriptional repressor in a promoter-specicic manner, the function probbaly involves association with histone deacetylases, such as HDAC1. As component of a large PER complex is involved in the inhibition of 3\\\' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms.

Aliases: ATP dependent RNA helicase DDX5 antibody, DDX 5 antibody, Ddx5 antibody, DDX5_HUMAN antibody, DEAD (Asp Glu Ala Asp) box helicase 5 antibody, DEAD (Asp Glu Ala Asp) box polypeptide 5 antibody, DEAD box 5 antibody, DEAD box protein 5 antibody, DEAD/H (Asp Glu Ala Asp/His) box polypeptide 5 (RNA helicase, 68kD) antibody, G17P1 antibody, HELR antibody, HLR1 antibody, HUMP68 antibody, P68 antibody, p68 RNA helicase antibody, Probable ATP dependent RNA helicase DDX5 antibody, Probable ATP-dependent RNA helicase DDX5 antibody, RNA helicase p68 antibody

UniProt: P17844

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Regulation of Muscle Cell Differentiation, Positive Regulation of Response to DNA Damage Stimulus