UXT antibody (AA 1-157)

Catalog No. ABIN7166273

This Rabbit Polyclonal antibody specifically detects UXT in WB, ELISA and IHC. It exhibits reactivity toward Human.

Quick Overview for UXT antibody (AA 1-157) (ABIN7166273)

Target: UXT (Ubiquitously-Expressed, Prefoldin-Like Chaperone (UXT))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UXT antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-UXT Antibody

Binding Specificity: AA 1-157

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Protein UXT protein (1-157AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for UXT

Target: UXT (Ubiquitously-Expressed, Prefoldin-Like Chaperone (UXT))

Alternative Name: UXT

Background:

Background: Involved in gene transcription regulation. Acts in concert with the corepressor URI1 to regulate androgen receptor transcription (AR). AR N-terminus-associated coactivator which may play a role in facilitating receptor-induced transcriptional activation (PubMed:11854421). Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling (PubMed:11827465). Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC (PubMed:17554592). May be a nuclear chaperone that promotes formation of the NF-kappa-B enhanceosome and which is essential for its nuclear function (PubMed:17620405). Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM (PubMed:17635584). Together with URI1, associates with chromatin to the NKX3-1 promoter region.

Aliases: Androgen receptor trapped clone 27 protein antibody, ART 27 antibody, ART-27 antibody, OTTHUMP00000023226 antibody, OTTHUMP00000023227 antibody, Protein UXT antibody, SKP2 associated alpha PFD 1 antibody, STAP1 antibody, Ubiquitously expressed prefoldin like chaperone antibody, Ubiquitously expressed transcript antibody, Ubiquitously expressed transcript protein antibody, Uxt antibody, UXT_HUMAN antibody

UniProt: Q9UBK9

Pathways: Unfolded Protein Response