RSAD2 antibody (AA 42-361)

Catalog No. ABIN7167058

This anti-RSAD2 antibody is a Rabbit Polyclonal antibody detecting RSAD2 in WB, ELISA and IHC. Suitable for Human.

Quick Overview for RSAD2 antibody (AA 42-361) (ABIN7167058)

Target: RSAD2 (Radical S-Adenosyl Methionine Domain Containing 2 (RSAD2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RSAD2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-RSAD2 Antibody

Binding Specificity: AA 42-361

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Radical S-adenosyl methionine domain-containing protein 2 protein (42-361AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:200-1:1000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for RSAD2

Target: RSAD2 (Radical S-Adenosyl Methionine Domain Containing 2 (RSAD2))

Alternative Name: RSAD2

Background:

Background: Interferon-inducible iron-sulfur (4FE-4S) cluster-binding antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Can inhibit a wide range of DNA and RNA viruses, including human cytomegalovirus (HCMV), hepatitis C virus (HCV), west Nile virus (WNV), dengue virus, sindbis virus, influenza A virus, sendai virus, vesicular stomatitis virus (VSV), and human immunodeficiency virus (HIV-1). Displays antiviral activity against influenza A virus by inhibiting the budding of the virus from the plasma membrane by disturbing the lipid rafts. This is accomplished, at least in part, through binding and inhibition of the enzyme farnesyl diphospate synthase (FPPS), which is essential for the biosynthesis of isoprenoid-derived lipids. Promotes TLR7 and TLR9-dependent production of IFN-beta production in plasmacytoid dendritic cells (pDCs) by facilitating Lys-63\\\'-linked ubiquitination of IRAK1. Plays a role in CD4+ T-cells activation and differentiation. Facilitates T-cell receptor (TCR)-mediated GATA3 activation and optimal T-helper 2 (Th2) cytokine production by modulating NFKB1 and JUNB activities. Can inhibit secretion of soluble proteins.

Aliases: 2510004L01Rik antibody, cig 33 antibody, CIG 5 antibody, cig-33 antibody, CIG-5 antibody, CIG33 antibody, CIG5 antibody, Cytomegalovirus induced gene 5 protein antibody, Cytomegalovirus-induced gene 5 protein antibody, endoplasmic reticulum-associated antibody, interferon-inducible antibody, Radical S adenosyl methionine domain containing 2 antibody, Radical S-adenosyl methionine domain-containing protein 2 antibody, RSAD 2 antibody, Rsad2 antibody, RSAD2_HUMAN antibody, RSDA-2 antibody, VIG 1 antibody, vig1 antibody, Viperin antibody, Virus inhibitory protein antibody, virus inhibitory protein endoplasmic reticulum associated interferon inducible antibody

UniProt: Q8WXG1

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response