RanBP3 antibody (AA 1-250)

Catalog No. ABIN7167095

This Rabbit Polyclonal antibody specifically detects RanBP3 in WB, ELISA and IHC. It exhibits reactivity toward Human.

Quick Overview for RanBP3 antibody (AA 1-250) (ABIN7167095)

Target: RanBP3 (RANBP3) (RAN Binding Protein 3 (RANBP3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RanBP3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-RanBP3 Antibody

Binding Specificity: AA 1-250

Purpose: RANBP3 Antibody

Cross-Reactivity: Mouse

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Ran-binding protein 3 protein (1-250AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for RanBP3

Target: RanBP3 (RANBP3) (RAN Binding Protein 3 (RANBP3))

Alternative Name: RANBP3

Background:

Background: Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export.

Aliases: DKFZp586I1520 antibody, Ran binding protein 3 antibody, Ran-binding protein 3 antibody, RANB3_HUMAN antibody, RanBP3 antibody

UniProt: Q9H6Z4