RAB11A antibody (AA 2-213) (Biotin)

Catalog No. ABIN7167222

The Rabbit Polyclonal anti-RAB11A antibody has been validated for ELISA. It is suitable to detect RAB11A in samples from Human.

Quick Overview for RAB11A antibody (AA 2-213) (Biotin) (ABIN7167222)

Target: RAB11A (RAB11A, Member RAS Oncogene Family (RAB11A))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RAB11A antibody is conjugated to Biotin

Application: ELISA

Product Details anti-RAB11A Antibody (Biotin)

Binding Specificity: AA 2-213

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Ras-related protein Rab-11A protein (2-213AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for RAB11A

Target: RAB11A (RAB11A, Member RAS Oncogene Family (RAB11A))

Alternative Name: RAB11A

Background:

Background: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes. May also play a role in melanosome transport and release from melanocytes.

Aliases: MGC1490 antibody, Rab 11 antibody, Rab 11A antibody, RAB 11A, member oncogene family antibody, Rab-11 antibody, RAB11 A antibody, RAB11 antibody, Rab11a antibody, RAB11A member RAS oncogene family antibody, Ras related protein Rab 11A antibody, Ras related protein Rab11A antibody, Ras-related protein Rab-11A antibody, RB11A_HUMAN antibody, YL 8 antibody, YL8 antibody

UniProt: P62491

Pathways: Regulation of Cell Size, Thromboxane A2 Receptor Signaling, Regulation of long-term Neuronal Synaptic Plasticity