RTEL1 antibody (AA 975-1219)

Catalog No. ABIN7167648

The Rabbit Polyclonal anti-RTEL1 antibody has been validated for ELISA, IHC and IF. It is suitable to detect RTEL1 in samples from Human.

Quick Overview for RTEL1 antibody (AA 975-1219) (ABIN7167648)

Target: RTEL1 (Regulator of Telomere Elongation Helicase 1 (RTEL1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RTEL1 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-RTEL1 Antibody

Binding Specificity: AA 975-1219

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Regulator of telomere elongation helicase 1 protein (975-1219AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for RTEL1

Target: RTEL1 (Regulator of Telomere Elongation Helicase 1 (RTEL1))

Alternative Name: RTEL1

Background:

Background: ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by counteracting telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere.

Aliases: RTEL1 antibody, C20orf41 antibody, KIAA1088 antibody, NHLRegulator of telomere elongation helicase 1 antibody, EC 3.6.4.12 antibody, Novel helicase-like antibody

UniProt: Q9NZ71