RGMA antibody (AA 153-408) (FITC)

Catalog No. ABIN7167711

The Rabbit Polyclonal anti-RGMA antibody has been validated for . It is suitable to detect RGMA in samples from Human.

Quick Overview for RGMA antibody (AA 153-408) (FITC) (ABIN7167711)

Target: RGMA (RGM Domain Family, Member A (RGMA))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RGMA antibody is conjugated to FITC

Application: Please inquire

Product Details anti-RGMA Antibody (FITC)

Binding Specificity: AA 153-408

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Repulsive guidance molecule A protein (153-408AA)

Isotype: IgG

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for RGMA

Target: RGMA (RGM Domain Family, Member A (RGMA))

Alternative Name: RGMA

Background:

Background: Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.

Aliases: Repulsive guidance molecule A antibody, RGM antibody, RGM domain family member A antibody, RGMA antibody, RGMA_HUMAN antibody

UniProt: Q96B86

Pathways: Tube Formation