RBM4 antibody (AA 121-205) (Biotin)

Catalog No. ABIN7168346

This Rabbit Polyclonal antibody specifically detects RBM4 in ELISA. It exhibits reactivity toward Human.

Quick Overview for RBM4 antibody (AA 121-205) (Biotin) (ABIN7168346)

Target: RBM4 (RNA Binding Motif Protein 4 (RBM4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RBM4 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-RBM4 Antibody (Biotin)

Binding Specificity: AA 121-205

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human RNA-binding protein 4 protein (121-205AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for RBM4

Target: RBM4 (RNA Binding Motif Protein 4 (RBM4))

Alternative Name: RBM4

Background:

Background: RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5\\\'-splice site and exon selection. Acts as a muscle cell differentiation-promoting factor. Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation. Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin. Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs. Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3\\\'-UTR of the PER1 mRNA. Exerts a suppressive activity on Cap-dependent translation via binding to CU-rich responsive elements within the 3\\\'UTR of mRNAs, a process increased under stress conditions or during myocytes differentiation. Recruits EIF4A1 to stimulate IRES-dependent translation initiation in respons to cellular stress. Associates to internal ribosome entry segment (IRES) in target mRNA species under stress conditions. Plays a role for miRNA-guided RNA cleavage and translation suppression by promoting association of AGO2-containing miRNPs with their cognate target mRNAs. Associates with miRNAs during muscle cell differentiation. Binds preferentially to 5\\\'-CGCGCG[GCA]-3\\\' motif in vitro.

Aliases: dkfzp547k0918 antibody, hLark antibody, lark antibody, Lark homolog antibody, lark homologue antibody, mgc75138 antibody, RBM4 antibody, rbm4 lark antibody, RBM4_HUMAN antibody, RNA binding motif 4 antibody, RNA binding motif 4a antibody, RNA-binding motif protein 4 antibody, RNA-binding motif protein 4a antibody, RNA-binding protein 4 antibody

UniProt: Q9BWF3

Pathways: Regulation of Muscle Cell Differentiation, Photoperiodism