SENP6 antibody (AA 1-270) (HRP)

Catalog No. ABIN7168844

This Rabbit Polyclonal antibody specifically detects SENP6 in ELISA. It exhibits reactivity toward Human.

Quick Overview for SENP6 antibody (AA 1-270) (HRP) (ABIN7168844)

Target: SENP6 (SUMO1/sentrin Specific Protease 6 (SENP6))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SENP6 antibody is conjugated to HRP

Application: ELISA

Product Details anti-SENP6 Antibody (HRP)

Binding Specificity: AA 1-270

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Sentrin-specific protease 6 protein (1-270AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for SENP6

Target: SENP6 (SUMO1/sentrin Specific Protease 6 (SENP6))

Alternative Name: SENP6

Background:

Background: Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination.

Aliases: 2810017C20Rik antibody, FLJ11355 antibody, FLJ11887 antibody, KIAA0389 antibody, KIAA0797 antibody, SENP 6 antibody, Senp6 antibody, SENP6_HUMAN antibody, Sentrin specific protease 6 antibody, Sentrin-specific protease 6 antibody, Sentrin/SUMO specific protease SENP6 antibody, Sentrin/SUMO-specific protease SENP6 antibody, SSP 1 antibody, SSP1 antibody, SUMO 1 specific protease 1 antibody, SUMO 1 specific protease antibody, SUMO-1-specific protease 1 antibody, SUMO1 specific protease 1 antibody, SUMO1 specific protease antibody, SUMO1/sentrin specific peptidase 6 antibody, SUSP 1 antibody, SUSP1 antibody

UniProt: Q9GZR1