MASTL antibody (AA 612-740) (HRP)

Catalog No. ABIN7169046

The Rabbit Polyclonal anti-MASTL antibody has been validated for ELISA. It is suitable to detect MASTL in samples from Human.

Quick Overview for MASTL antibody (AA 612-740) (HRP) (ABIN7169046)

Target: MASTL (Microtubule Associated serine/threonine Kinase-Like (MASTL))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MASTL antibody is conjugated to HRP

Application: ELISA

Product Details anti-MASTL Antibody (HRP)

Binding Specificity: AA 612-740

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Serine/threonine-protein kinase greatwall protein (612-740AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for MASTL

Target: MASTL (Microtubule Associated serine/threonine Kinase-Like (MASTL))

Alternative Name: MASTL

Background:

Background: Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at \'Ser-62\' and \'Ser-67\', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro, however such activity is unsure in vivo. May be involved in megakaryocyte differentiation.

Aliases: 2700091H24Rik antibody, C88295 antibody, FLJ14813 antibody, GREATWALL antibody, Greatwall protein kinase antibody, GW antibody, GWL antibody, GWL_HUMAN antibody, hGWL antibody, MAST-L antibody, Mastl antibody, MGC117975 antibody, Microtubule associated serine/threonine kinase like antibody, Microtubule-associated serine/threonine-protein kinase-like antibody, RP11 85G18.2 antibody, Serine/threonine-protein kinase greatwall antibody, THC2 antibody

UniProt: Q96GX5