PAK3 antibody (AA 70-190) (HRP)

Catalog No. ABIN7169131

This anti-PAK3 antibody is a Rabbit Polyclonal antibody detecting PAK3 in ELISA. Suitable for Human.

Quick Overview for PAK3 antibody (AA 70-190) (HRP) (ABIN7169131)

Target: PAK3

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PAK3 antibody is conjugated to HRP

Application: ELISA

Product Details anti-PAK3 Antibody (HRP)

Binding Specificity: AA 70-190

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Serine/threonine-protein kinase PAK 3 protein (70-190AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PAK3

Target: PAK3

Alternative Name: PAK3

Background:

Background: Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development.

Aliases: PAK3 antibody, OPHN3 antibody, Serine/threonine-protein kinase PAK 3 antibody, EC 2.7.11.1 antibody, Beta-PAK antibody, Oligophrenin-3 antibody, p21-activated kinase 3 antibody, PAK-3 antibody

UniProt: O75914