PPP2CA antibody (Catalytic Subunit alpha)

Catalog No. ABIN7169266

This anti-PPP2CA antibody is a Rabbit Polyclonal antibody detecting PPP2CA in WB, ELISA, IHC and IF. Suitable for Human.

Quick Overview for PPP2CA antibody (Catalytic Subunit alpha) (ABIN7169266)

Target: PPP2CA (Protein Phosphatase 2, Catalytic Subunit, alpha Isozyme (PPP2CA))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PPP2CA antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-PPP2CA Antibody

Binding Specificity: AA 1-309, Catalytic Subunit alpha

Cross-Reactivity: Human, Mouse

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform protein (1-309AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PPP2CA

Target: PPP2CA (Protein Phosphatase 2, Catalytic Subunit, alpha Isozyme (PPP2CA))

Alternative Name: PPP2CA

Background:

Background: PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at \\\'Ser-259\\\'.

Aliases: PP2A A antibody, PP2A alpha antibody, PP2A B antibody, PP2A beta antibody, PP2A-alpha antibody, PP2A-beta antibody, PP2AA_HUMAN antibody, PP2Aalpha antibody, PP2AB_HUMAN antibody, PP2Abeta antibody, PP2Ac antibody, PP2CA antibody, PP2Calpha antibody, PP2CB antibody, PPP2CA antibody, PPP2CB antibody, Protein phosphatase 2 catalytic subunit alpha isoform antibody, Protein phosphatase 2 catalytic subunit beta isoform antibody, Protein phosphatase type 2A catalytic subunit antibody, Replication protein C antibody, RP C antibody, RP-C antibody, RPC antibody, Serine/threonine protein phosphatase 2A catalytic subunit alpha isoform antibody, Serine/threonine protein phosphatase 2A catalytic subunit beta isoform antibody, Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform antibody

UniProt: P67775

Pathways: PI3K-Akt Signaling, Mitotic G1-G1/S Phases, Hepatitis C, Toll-Like Receptors Cascades