SHARPIN antibody (AA 82-171) (Biotin)

Catalog No. ABIN7169504

This Rabbit Polyclonal antibody specifically detects SHARPIN in ELISA. It exhibits reactivity toward Human.

Quick Overview for SHARPIN antibody (AA 82-171) (Biotin) (ABIN7169504)

Target: SHARPIN (SHANK-Associated RH Domain Interacting Protein (SHARPIN))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SHARPIN antibody is conjugated to Biotin

Application: ELISA

Product Details anti-SHARPIN Antibody (Biotin)

Binding Specificity: AA 82-171

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Sharpin protein (82-171AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for SHARPIN

Target: SHARPIN (SHANK-Associated RH Domain Interacting Protein (SHARPIN))

Alternative Name: SHARPIN

Background:

Background: Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis.

Aliases: DKFZp434N1923 antibody, hSIPL1 antibody, Shank associated RH domain interacting protein antibody, SHANK associated RH domain interactor antibody, Shank interacting protein like 1 antibody, Shank-associated RH domain-interacting protein antibody, Shank-interacting protein-like 1 antibody, Sharpin antibody, SHRPN_HUMAN antibody, SIPL1 antibody

UniProt: Q9H0F6