SNX6 antibody (AA 1-290) (Biotin)

Catalog No. ABIN7170403

This anti-SNX6 antibody is a Rabbit Polyclonal antibody detecting SNX6 in ELISA. Suitable for Human.

Quick Overview for SNX6 antibody (AA 1-290) (Biotin) (ABIN7170403)

Target: SNX6 (Sorting Nexin 6 (SNX6))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SNX6 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-SNX6 Antibody (Biotin)

Binding Specificity: AA 1-290

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Sorting nexin-6 protein (1-290AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for SNX6

Target: SNX6 (Sorting Nexin 6 (SNX6))

Alternative Name: SNX6

Background:

Background: Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:19935774). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptor IGF2R (PubMed:17148574). May function as link between transport vesicles and dynactin (Probable). Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network (PubMed:20354142). Involved in E-cadherin sorting and degradation, inhibits PIP5K1C isoform 3-mediated E-cadherin degradation (PubMed:24610942). In association with GIT1 involved in EGFR degradation. Promotes lysosomal degradation of CDKN1B (By similarity). May contribute to transcription regulation (Probable).

Aliases: SNX6 antibody, Sorting nexin-6 antibody, TRAF4-associated factor 2) [Cleaved into: Sorting nexin-6 antibody, N-terminally processed] antibody

UniProt: Q9UNH7

Pathways: EGFR Signaling Pathway