SAMD8 antibody (AA 1-152) (Biotin)

Catalog No. ABIN7170562

This anti-SAMD8 antibody is a Rabbit Polyclonal antibody detecting SAMD8 in ELISA. Suitable for Human.

Quick Overview for SAMD8 antibody (AA 1-152) (Biotin) (ABIN7170562)

Target: SAMD8 (Sterile alpha Motif Domain Containing 8 (SAMD8))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SAMD8 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-SAMD8 Antibody (Biotin)

Binding Specificity: AA 1-152

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Sphingomyelin synthase-related protein 1 protein (1-152AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for SAMD8

Target: SAMD8 (Sterile alpha Motif Domain Containing 8 (SAMD8))

Alternative Name: SAMD8

Background:

Background: Sphingomyelin synthases synthesize sphingolipids through transfer of a phosphatidyl head group on to the primary hydroxyl of ceramide. SAMD8 is an endoplasmic reticulum (ER) transferase that has no sphingomyelin synthase activity but can convert phosphatidylethanolamine (PE) and ceramide to ceramide phosphoethanolamine (CPE) albeit with low product yield. Appears to operate as a ceramide sensor to control ceramide homeostasis in the endoplasmic reticulum rather than a converter of ceramides. Seems to be critical for the integrity of the early secretory pathway.

Aliases: SAMD8Sphingomyelin synthase-related protein 1 antibody, SMSr antibody, EC 2.7.8.- antibody, Ceramide phosphoethanolamine synthase antibody, CPE synthase antibody, Sterile alpha motif domain-containing protein 8 antibody, SAM domain-containing protein 8 antibody

UniProt: Q96LT4