S1PR1 antibody (AA 311-382)

Catalog No. ABIN7170565

This anti-S1PR1 antibody is a Rabbit Polyclonal antibody detecting S1PR1 in WB, ELISA, IF and IHC. Suitable for Human.

Quick Overview for S1PR1 antibody (AA 311-382) (ABIN7170565)

Target: S1PR1 (Sphingosine-1-Phosphate Receptor 1 (S1PR1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This S1PR1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC)

Product Details anti-S1PR1 Antibody

Binding Specificity: AA 311-382

Cross-Reactivity: Human, Mouse

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Sphingosine 1-phosphate receptor 1 protein (311-382AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for S1PR1

Target: S1PR1 (Sphingosine-1-Phosphate Receptor 1 (S1PR1))

Alternative Name: S1PR1

Background:

Background: G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis (By similarity). Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury.

Aliases: CD363 antibody, CHEDG 1 antibody, CHEDG1 antibody, D1S3362 antibody, ECGF 1 antibody, ECGF1 antibody, EDG 1 antibody, EDG1 antibody, endothelial differentiation G protein coupled receptor 1 antibody, Endothelial differentiation G-protein coupled receptor 1 antibody, Endothelial differentiation sphingolipid G protein coupled receptor 1 antibody, FLJ58121 antibody, G protein coupled sphingolipid receptor antibody, g protein-coupled receptor edg-1 antibody, S1P receptor 1 antibody, S1P receptor Edg 1 antibody, S1P receptor Edg-1 antibody, S1P receptor Edg1 antibody, S1P(1) receptor antibody, S1P1 antibody, s1pr1 antibody, S1PR1_HUMAN antibody, sphingolipid g-protein-coupled receptor 1 antibody, Sphingosine 1 phosphate receptor Edg 1 antibody, Sphingosine 1 phosphate receptor EDG1 antibody, sphingosine 1- phosphate receptor 1 antibody, Sphingosine 1-phosphate receptor 1 antibody, Sphingosine 1-phosphate receptor Edg-1 antibody, Sphingosine 1phosphate receptor type 1 S1P1 antibody

UniProt: P21453

Pathways: Signaling Events mediated by VEGFR1 and VEGFR2