Spindlin 1 antibody (AA 1-262)

Catalog No. ABIN7170599

This Rabbit Polyclonal antibody specifically detects Spindlin 1 in WB, IHC and ELISA. It exhibits reactivity toward Human.

Quick Overview for Spindlin 1 antibody (AA 1-262) (ABIN7170599)

Target: Spindlin 1 (SPIN1)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Spindlin 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-Spindlin 1 Antibody

Binding Specificity: AA 1-262

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Spindlin-1 protein (1-262AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for Spindlin 1

Target: Spindlin 1 (SPIN1)

Alternative Name: SPIN1

Background:

Background: Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at \\\'Lys-4\\\' and asymmetrically dimethylated at \\\'Arg-8\\\' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway dowstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (PubMed:24589551). Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes (PubMed:21960006). May play a role in cell-cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption.

Aliases: OCR antibody, Ovarian cancer-related protein antibody, SPIN antibody, Spin1 antibody, SPIN1_HUMAN antibody, Spindlin-1 antibody

UniProt: Q9Y657