SRPK2 antibody (AA 471-688)

Catalog No. ABIN7170677

This Rabbit Polyclonal antibody specifically detects SRPK2 in WB, ELISA and IHC. It exhibits reactivity toward Human.

Quick Overview for SRPK2 antibody (AA 471-688) (ABIN7170677)

Target: SRPK2 (SFRS Protein Kinase 2 (SRPK2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SRPK2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-SRPK2 Antibody

Binding Specificity: AA 471-688

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human SRSF protein kinase 2 protein (471-688AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for SRPK2

Target: SRPK2 (SFRS Protein Kinase 2 (SRPK2))

Alternative Name: SRPK2

Background:

Background: Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation. Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28. Can mediate hepatitis B virus (HBV) core protein phosphorylation. Plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles.

Aliases: Human serine kinase SRPK2 mRNA, complete cds antibody, Serine kinase SRPK2 antibody, Serine/arginine rich protein specific kinase 2 antibody, Serine/arginine-rich protein-specific kinase 2 antibody, Serine/threonine protein kinase SRPK2 antibody, SFRS protein kinase 2 antibody, SFRSK2 antibody, SR protein specific kinase 2 antibody, SR-protein-specific kinase 2 antibody, SRPK2 antibody, SRPK2_HUMAN antibody, SRSF protein kinase 2 C-terminal antibody

UniProt: P78362

Pathways: Ribonucleoprotein Complex Subunit Organization