STING/TMEM173 antibody (AA 207-379) (HRP)

Catalog No. ABIN7170797

This Rabbit Polyclonal antibody specifically detects STING/TMEM173 in ELISA. It exhibits reactivity toward Human.

Quick Overview for STING/TMEM173 antibody (AA 207-379) (HRP) (ABIN7170797)

Target: STING/TMEM173 (TMEM173) (Transmembrane Protein 173 (TMEM173))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STING/TMEM173 antibody is conjugated to HRP

Application: ELISA

Product Details anti-STING/TMEM173 Antibody (HRP)

Binding Specificity: AA 207-379

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Stimulator of interferon genes protein (207-379AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for STING/TMEM173

Target: STING/TMEM173 (TMEM173) (Transmembrane Protein 173 (TMEM173))

Alternative Name: TMEM173

Background:

Background: Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated and TMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway. Essential for the induction of IFN-beta in response to human herpes simplex virus 1 (HHV-1) infection. Exhibits 2\',3\' phosphodiester linkage-specific ligand recognition. Can bind both 2\'-3\' linked cGAMP and 3\'-3\' linked cGAMP but is preferentially activated by 2\'-3\' linked cGAMP (PubMed:26300263).

Aliases: endoplasmic reticulum IFN stimulator antibody, Endoplasmic reticulum interferon stimulator antibody, ERIS antibody, FLJ38577 antibody, hMITA antibody, hSTING antibody, Mediator of IRF3 activation antibody, MITA antibody, Mitochondrial mediator of IRF3 activation antibody, MPYS antibody, N terminal methionine proline tyrosine serine plasma membrane tetraspanner antibody, NET23 antibody, Stimulator of interferon genes antibody, Stimulator of interferon genes protein antibody, STING antibody, TM173_HUMAN antibody, Tmem173 antibody, Transmembrane protein 173 antibody

UniProt: Q86WV6

Pathways: Activation of Innate immune Response