TIAM2 antibody (AA 1500-1627) (Biotin)

Catalog No. ABIN7171463

This Rabbit Polyclonal antibody specifically detects TIAM2 in ELISA. It exhibits reactivity toward Human.

Quick Overview for TIAM2 antibody (AA 1500-1627) (Biotin) (ABIN7171463)

Target: TIAM2 (T-Cell Lymphoma Invasion and Metastasis 2 (TIAM2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TIAM2 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-TIAM2 Antibody (Biotin)

Binding Specificity: AA 1500-1627

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human T-lymphoma invasion and metastasis-inducing protein 2 protein (1500-1627AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for TIAM2

Target: TIAM2 (T-Cell Lymphoma Invasion and Metastasis 2 (TIAM2))

Alternative Name: TIAM2

Background:

Background: Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane (By similarity). Activates specifically RAC1, but not CDC42 and RHOA.

Aliases: FLJ41865 antibody, OTTHUMP00000017472 antibody, SIF and TIAM1 like exchange factor antibody, SIF and TIAM1-like exchange factor antibody, STEF antibody, T cell lymphoma invasion and metastasis 2 antibody, T lymphoma invasion and metastasis inducing protein 2 antibody, T-lymphoma invasion and metastasis-inducing protein 2 antibody, TIAM 2 antibody, TIAM-2 antibody, Tiam2 antibody, TIAM2_HUMAN antibody

UniProt: Q8IVF5

Pathways: Neurotrophin Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha