ERCC2 antibody (AA 1-300)

Catalog No. ABIN7171956

The Rabbit Polyclonal anti-ERCC2 antibody has been validated for WB, ELISA and IHC. It is suitable to detect ERCC2 in samples from Human.

Quick Overview for ERCC2 antibody (AA 1-300) (ABIN7171956)

Target: ERCC2 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ERCC2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-ERCC2 Antibody

Binding Specificity: AA 1-300

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human TFIIH basal transcription factor complex helicase XPD subunit protein (1-300AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for ERCC2

Target: ERCC2 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2))

Alternative Name: ERCC2

Background:

Background: ATP-dependent 5\\\'-3\\\' DNA helicase, component of the core-TFIIH basal transcription factor. Involved in nucleotide excision repair (NER) of DNA by opening DNA around the damage, and in RNA transcription by RNA polymerase II by anchoring the CDK-activating kinase (CAK) complex, composed of CDK7, cyclin H and MAT1, to the core-TFIIH complex. Involved in the regulation of vitamin-D receptor activity. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation. Might have a role in aging process and could play a causative role in the generation of skin cancers.

Aliases: TFIIH 80 kDa subunit antibody, Basic transcription factor 2 80 kDa subunit antibody, BTF2 p80 antibody, COFS 2 antibody, COFS2 antibody, CXPD antibody, DNA excision repair protein ERCC 2 antibody, DNA excision repair protein ERCC-2 antibody, DNA repair protein complementing XP D cells antibody, DNA repair protein complementing XP-D cells antibody, EM9 antibody, ERCC 2 antibody, ERCC2 antibody, ERCC2_HUMAN antibody, Excision repair 2 antibody, Excision repair cross complementing rodent repair deficiency complementation antibody, Excision repair cross complementing rodent repair deficiency, complementation group 2 antibody, MAG antibody, MGC102762 antibody, MGC126218 antibody, MGC126219 antibody, OTTHUMP00000045860 antibody, OTTHUMP00000045861 antibody, OTTHUMP00000045862 antibody, OTTHUMP00000045863 antibody, TFIIH 80 kDa subunit antibody, TFIIH basal transcription factor complex 80 kDa subunit antibody, TFIIH Basal Transcription Factor Complex Helicase Subunit antibody, TFIIH basal transcription factor complex helicase XPD subunit antibody, TFIIH basal transcription factor complex p80 subunit antibody, TFIIH p80 antibody, TTD antibody, Xeroderma pigmentosum complementary group D antibody, Xeroderma pigmentosum group D complementing protein antibody, Xeroderma pigmentosum group D-complementing protein antibody, XPD antibody, XPDC antibody

UniProt: P18074

Pathways: DNA Damage Repair