TGFBR1 antibody (AA 157-244)

Catalog No. ABIN7171957

This anti-TGFBR1 antibody is a Rabbit Polyclonal antibody detecting TGFBR1 in WB, ELISA, IHC and IF. Suitable for Human.

Quick Overview for TGFBR1 antibody (AA 157-244) (ABIN7171957)

Target: TGFBR1 (Transforming Growth Factor, beta Receptor 1 (TGFBR1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TGFBR1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-TGFBR1 Antibody

Binding Specificity: AA 157-244

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human TGF-beta receptor type-1 protein (157-244AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IHC:1:1000-1:2000, IF:1:200-1:500,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for TGFBR1

Target: TGFBR1 (Transforming Growth Factor, beta Receptor 1 (TGFBR1))

Alternative Name: TGFBR1

Background:

Background: Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 Molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. For instance, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and activation to trigger apoptosis. Also regulates epithelial to mesenchymal transition through a SMAD-independent signaling pathway through PARD6A phosphorylation and activation.

Aliases: AAT 5 antibody, AAT5 antibody, Activin A receptor type II like kinase 53 kDa antibody, Activin A receptor type II like kinase antibody, Activin A receptor type II like kinase, 53kD antibody, Activin A receptor type II like protein kinase of 53kD antibody, activin A receptor type II-like kinase, 53 kDa antibody, activin A receptor type II-like protein kinase of 53kD antibody, Activin receptor like kinase 5 antibody, Activin receptor-like kinase 5 antibody, ACVRLK 4 antibody, ACVRLK4 antibody, ALK 5 antibody, ALK-5 antibody, ALK5 antibody, LDS1A antibody, LDS2A antibody, MSSE antibody, Serine/threonine protein kinase receptor R4 antibody, Serine/threonine-protein kinase receptor R4 antibody, SKR 4 antibody, SKR4 antibody, TbetaR I antibody, TbetaR-I antibody, TGF beta receptor type 1 antibody, TGF beta receptor type I antibody, TGF beta type I receptor antibody, TGF-beta receptor type I antibody, TGF-beta receptor type-1 antibody, TGF-beta type I receptor antibody, TGFBR 1 antibody, TGFBR1 antibody, TGFBR1 protein antibody, TGFR 1 antibody, TGFR-1 antibody, TGFR1 antibody, TGFR1_HUMAN antibody, Transforming growth factor beta receptor 1 antibody, Transforming growth factor beta receptor I (activin A receptor type II like kinase, 53kD) antibody, Transforming growth factor beta receptor I antibody, transforming growth factor, beta receptor 1 antibody, transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kD) antibody, Transforming growth factor-beta receptor type I antibody

UniProt: P36897

Pathways: Growth Factor Binding