TRAF2 antibody (AA 147-281)

Catalog No. ABIN7172232

The Rabbit Polyclonal anti-TRAF2 antibody has been validated for ELISA, IHC and IF. It is suitable to detect TRAF2 in samples from Human.

Quick Overview for TRAF2 antibody (AA 147-281) (ABIN7172232)

Target: TRAF2 (TNF Receptor-Associated Factor 2 (TRAF2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRAF2 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-TRAF2 Antibody

Binding Specificity: AA 147-281

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human TNF receptor-associated factor 2 protein (147-281AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for TRAF2

Target: TRAF2 (TNF Receptor-Associated Factor 2 (TRAF2))

Alternative Name: TRAF2

Background:

Background: Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes \'Lys-63\'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation, this does not depend on the TRAF2 RING-type zinc finger domain. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. In complex with BIRC2 or BIRC3, promotes ubiquitination of IKBKE.

Aliases: E3 ubiquitin-protein ligase TRAF2 antibody, MGC:45012 antibody, OTTHUMP00000022625 antibody, OTTHUMP00000064745 antibody, TNF receptor associated factor 2 antibody, TNF receptor-associated factor 2 antibody, TNF receptor-associated protein antibody, TRAF 2 antibody, TRAF2 antibody, TRAF2_HUMAN antibody, TRAP 3 antibody, TRAP antibody, TRAP3 antibody, Tumor necrosis factor type 2 receptor associated protein 3 antibody, Tumor necrosis factor type 2 receptor-associated protein 3 antibody

UniProt: Q12933

Pathways: NF-kappaB Signaling, Apoptosis, Caspase Cascade in Apoptosis, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Hepatitis C, Unfolded Protein Response, S100 Proteins