TRIAP1 antibody (AA 1-76)

Catalog No. ABIN7172318

This Rabbit Polyclonal antibody specifically detects TRIAP1 in ELISA and IHC. It exhibits reactivity toward Human.

Quick Overview for TRIAP1 antibody (AA 1-76) (ABIN7172318)

Target: TRIAP1 (TP53 Regulated Inhibitor of Apoptosis 1 (TRIAP1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRIAP1 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Product Details anti-TRIAP1 Antibody

Binding Specificity: AA 1-76

Purpose: TRIAP1 Antibody

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human TP53-regulated inhibitor of apoptosis 1 protein (1-76AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for TRIAP1

Target: TRIAP1 (TP53 Regulated Inhibitor of Apoptosis 1 (TRIAP1))

Alternative Name: TRIAP1

Background:

Background: Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane (PubMed:23931759). Likewise, the TRIAP1:PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes (in vitro) and probably functions as a PA transporter across the mitochondrion intermembrane space (in vivo) (PubMed:26071602). Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis (PubMed:15735003).

Aliases: p53-inducible cell-survival factor antibody, p53CSV antibody, Protein 15E1.1 antibody, TP53-regulated inhibitor of apoptosis 1 antibody, TRIA1_HUMAN antibody, Triap1 antibody, WF 1 antibody, WF1 antibody

UniProt: O43715

Pathways: Negative Regulation of intrinsic apoptotic Signaling