TNIK antibody (AA 523-714) (HRP)

Catalog No. ABIN7172343

The Rabbit Polyclonal anti-TNIK antibody has been validated for ELISA. It is suitable to detect TNIK in samples from Human.

Quick Overview for TNIK antibody (AA 523-714) (HRP) (ABIN7172343)

Target: TNIK (TRAF2 and NCK Interacting Kinase (TNIK))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TNIK antibody is conjugated to HRP

Application: ELISA

Product Details anti-TNIK Antibody (HRP)

Binding Specificity: AA 523-714

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human TRAF2 and NCK-interacting protein kinase protein (523-714AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for TNIK

Target: TNIK (TRAF2 and NCK Interacting Kinase (TNIK))

Alternative Name: TNIK

Background:

Background: Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322.

Aliases: EC 2.7.11.1 antibody, KIAA0551 antibody, Tnik antibody, TNIK_HUMAN antibody, Traf2 and NCK interacting kinase antibody, Traf2 and NCK-interacting protein kinase antibody

UniProt: Q9UKE5