Protein C8orf4 (TCIM) (AA 1-106) antibody
Quick Overview for Protein C8orf4 (TCIM) (AA 1-106) antibody (ABIN7172749)
Target
Reactivity
Host
Clonality
Application
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Binding Specificity
- AA 1-106
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Purpose
- TCIM Antibody
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Purification
- Antigen Affinity Purified
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Immunogen
- Recombinant Human Transcriptional and immune response regulator protein (1-106AA)
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Isotype
- IgG
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
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Preservative
- Sodium azide
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Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
- -20 °C,-80 °C
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Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Protein C8orf4 (TCIM)
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Alternative Name
- TCIM
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Background
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Background: Seems to be involved in the regulation of cell growth an differentiation, may play different and opposite roles depending on the tissue or cell type. May enhance the WNT-CTNNB1 pathway by relieving antagonistic activity of CBY1 (PubMed:16424001, PubMed:16730711). Enhances the proliferation of follicular dendritic cells (PubMed:16730711). Plays a role in the mitogen-activated MAPK2/3 signaling pathway, positively regulates G1-to-S-phase transition of the cell cycle (PubMed:18959821). In endothelial cells, enhances key inflammatory mediators and inflammatory response through the modulation of NF-kappaB transcriptional regulatory activity (PubMed:19684084). Involved in the regulation of heat shock response, seems to play a positive feedback with HSF1 to modulate heat-shock downstream gene expression (PubMed:17603013). Plays a role in the regulation of hematopoiesis even if the mechanisms are unknown (By similarity). In cancers such as thyroid or lung cancer, it has been described as promoter of cell proliferation, G1-to-S-phase transition and inhibitor of apoptosis (PubMed:15087392, PubMed:24941347). However, it negatively regulates self-renewal of liver cancer cells via suppresion of NOTCH2 signaling (PubMed:25985737).
Aliases: C8orf4 antibody, CH004_HUMAN antibody, Chromosome 8 open reading frame 4 antibody, Human thyroid cancer 1 antibody, MGC22806 antibody, TC-1 antibody, TC1 antibody, Thyroid cancer protein 1 antibody, Uncharacterized protein C8orf4 antibody
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UniProt
- Q9NR00
Target
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