CTCFL antibody (AA 1-270)

Catalog No. ABIN7172781

The Rabbit Polyclonal anti-CTCFL antibody has been validated for ELISA and IHC. It is suitable to detect CTCFL in samples from Human.

Quick Overview for CTCFL antibody (AA 1-270) (ABIN7172781)

Target: CTCFL (CCCTC-Binding Factor (Zinc Finger Protein)-Like (CTCFL))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CTCFL antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Product Details anti-CTCFL Antibody

Binding Specificity: AA 1-270

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Transcriptional repressor CTCFL protein (1-270AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CTCFL

Target: CTCFL (CCCTC-Binding Factor (Zinc Finger Protein)-Like (CTCFL))

Alternative Name: CTCFL

Background:

Background: Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 \\\'Arg-3\\\' to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases at these sites (By similarity). Seems to act as tumor suppressor. In association with DNMT1 and DNMT3B, involved in activation of BAG1 gene expression by binding to its promoter. Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters.

Aliases: BORIS like protein antibody, Brother of the regulator of imprinted sites antibody, Cancer/testis antigen 27 antibody, CCCTC binding factor (zinc finger protein) like antibody, CCCTC-binding factor antibody, CT27 antibody, CTCF paralog antibody, CTCF T antibody, CTCF-like protein antibody, Ctcfl antibody, CTCFL_HUMAN antibody, dJ579F20.2 antibody, HMG 1L1 antibody, HMGB1L1 antibody, MGC163358 antibody, MGC169105 antibody, MGC169106 antibody, Putative high mobility group protein 1 like 1 antibody, Putative high mobility group protein B1 like 1 antibody, Transcriptional repressor CTCFL antibody, Zinc finger protein CTCF-T antibody

UniProt: Q8NI51