YES1 antibody (AA 1-155)

Catalog No. ABIN7174080

The Rabbit Polyclonal anti-YES1 antibody has been validated for WB, ELISA, IHC and IF. It is suitable to detect YES1 in samples from Human.

Quick Overview for YES1 antibody (AA 1-155) (ABIN7174080)

Target: YES1 (V-Yes-1 Yamaguchi Sarcoma Viral Oncogene Homolog 1 (YES1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This YES1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-YES1 Antibody

Binding Specificity: AA 1-155

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Tyrosine-protein kinase Yes protein (1-155AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for YES1

Target: YES1 (V-Yes-1 Yamaguchi Sarcoma Viral Oncogene Homolog 1 (YES1))

Alternative Name: YES1

Background:

Background: Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis.

Aliases: c Yes antibody, Cellular Yes 1 protein antibody, Cellular Yes1 protein antibody, HsT441 antibody, P61 YES antibody, p61-Yes antibody, Proto oncogene tyrosine protein kinase YES antibody, Proto-oncogene c-Yes antibody, Tyrosine-protein kinase Yes antibody, v yes 1 Yamaguchi sarcoma viral oncogene homolog 1 antibody, Viral oncogene yes 1 homolog 1 antibody, Viral oncogene yes1 homolog 1 antibody, Yamaguchi sarcoma oncogene antibody, Yes 1 antibody, Yes antibody, YES proto oncogene 1, Src family tyrosine kinase antibody, YES_HUMAN antibody, YES1 antibody, YES1 proto oncogene, Src family tyrosine kinase antibody

UniProt: P07947

Pathways: CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Thromboxane A2 Receptor Signaling