SIRPA antibody (AA 31-373) (Biotin)

Catalog No. ABIN7174126

This anti-SIRPA antibody is a Rabbit Polyclonal antibody detecting SIRPA in ELISA. Suitable for Human.

Quick Overview for SIRPA antibody (AA 31-373) (Biotin) (ABIN7174126)

Target: SIRPA (Signal-Regulatory Protein alpha (SIRPA))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SIRPA antibody is conjugated to Biotin

Application: ELISA

Product Details anti-SIRPA Antibody (Biotin)

Binding Specificity: AA 31-373

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Tyrosine-protein phosphatase non-receptor type substrate 1 protein (31-373AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for SIRPA

Target: SIRPA (Signal-Regulatory Protein alpha (SIRPA))

Alternative Name: SIRPA

Background:

Background: Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.

Aliases: Signal regulatory protein alpha type 1 antibody, Bit antibody, Brain Ig like molecule with tyrosine based activation motifs antibody, Brain Ig-like molecule with tyrosine-based activation motifs antibody, Brain immunoglobulin like molecule with tyrosine based activation motifs antibody, CD172 antigen like family member A antibody, CD172 antigen-like family member A antibody, CD172a antibody, CD172a antigen antibody, Inhibitory receptor SHPS-1 antibody, Macrophage fusion receptor antibody, MFR antibody, MYD 1 antibody, Myd 1 antigen antibody, MyD-1 antigen antibody, p84 antibody, Protein tyrosine phosphatase non receptor type substrate 1 antibody, PTPNS1 antibody, SHP substrate 1 antibody, SHPS-1 antibody, SHPS1 antibody, SHPS1_HUMAN antibody, Signal regulatory protein alpha 2 antibody, Signal regulatory protein alpha 3 antibody, Signal regulatory protein alpha antibody, Signal regulatory protein alpha type 2 antibody, Signal-regulatory protein alpha-1 antibody, Signal-regulatory protein alpha-2 antibody, Signal-regulatory protein alpha-3 antibody, SIRP antibody, Sirp-alpha-1 antibody, Sirp-alpha-2 antibody, Sirp-alpha-3 antibody, SIRPA antibody, SIRPalpha antibody, SIRPalpha1 antibody, SIRPalpha2 antibody, SIRPalpha3 antibody, Tyrosine phosphatase SHP substrate 1 antibody, Tyrosine protein phosphatase non receptor type substrate 1 antibody, Tyrosine-protein phosphatase non-receptor type substrate 1 antibody

UniProt: P78324