USP15 antibody (C-Term)

Catalog No. ABIN7174262

This Rabbit Polyclonal antibody specifically detects USP15 in ELISA and IHC. It exhibits reactivity toward Human.

Quick Overview for USP15 antibody (C-Term) (ABIN7174262)

Target: USP15 (Ubiquitin Specific Peptidase 15 (USP15))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This USP15 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Product Details anti-USP15 Antibody

Binding Specificity: AA 1-260, C-Term

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Ubiquitin carboxyl-terminal hydrolase 15 protein (1-260AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for USP15

Target: USP15 (Ubiquitin Specific Peptidase 15 (USP15))

Alternative Name: USP15

Background:

Background: Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling and NF-kappa-B pathways. Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes (PubMed:21947082). According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced TGF-beta signal (PubMed:22344298). Able to mediate deubiquitination of monoubiquitinated substrates as well as \\\'Lys-48\\\'-linked polyubiquitin chains, protecting them against proteasomal degradation. May also regulate gene expression and/or DNA repair through the deubiquitination of histone H2B (PubMed:24526689). Acts as an associated component of COP9 signalosome complex (CSN) and regulates different pathways via this association: regulates NF-kappa-B by mediating deubiquitination of NFKBIA and deubiquitinates substrates bound to VCP. Protects APC and human papillomavirus type 16 protein E6 against degradation via the ubiquitin proteasome pathway.

Aliases: Deubiquitinating enzyme 15 antibody, Deubiquitinating enzyme antibody, EC 3 1 2 15 antibody, KIAA0529 antibody, MGC131982 antibody, MGC149838 antibody, MGC74854 antibody, Ubiquitin Carboxy terminal Hydrolase 15 antibody, Ubiquitin carboxyl-terminal hydrolase 15 antibody, Ubiquitin specific peptidase 15 antibody, Ubiquitin specific processing protease 15 antibody, Ubiquitin Specific Protease 15 antibody, Ubiquitin thioesterase 15 antibody, Ubiquitin thiolesterase 15 antibody, Ubiquitin-specific-processing protease 15 antibody, UBP 15 antibody, UBP15 antibody, UBP15_HUMAN antibody, Unph 2 antibody, UNPH 4 antibody, Unph-2 antibody, Unph2 antibody, Unph4 antibody, USP 15 antibody, Usp15 antibody

UniProt: Q9Y4E8