Usp30 antibody (AA 101-400)

Catalog No. ABIN7174308

The Rabbit Polyclonal anti-Usp30 antibody is suitable to detect Usp30 in samples from Human. It has been validated for ELISA and IHC.

Quick Overview for Usp30 antibody (AA 101-400) (ABIN7174308)

Target: Usp30 (Ubiquitin Specific Peptidase 30 (Usp30))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Usp30 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Product Details anti-Usp30 Antibody

Binding Specificity: AA 101-400

Purpose: USP30 Antibody

Purification: Protein G purified

Purity: >95 %

Immunogen: Recombinant Human Ubiquitin carboxyl-terminal hydrolase 30 protein (101-400AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for Usp30

Target: Usp30 (Ubiquitin Specific Peptidase 30 (Usp30))

Alternative Name: USP30

Background:

Background: Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PARK2): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin\\\'s ability to drive mitophagy (PubMed:18287522, PubMed:24896179, PubMed:25527291, PubMed:25621951). Preferentially cleaves \\\'Lys-6\\\'- and \\\'Lys-11\\\'-linked polyubiquitin chains, 2 types of linkage that participate to mitophagic signaling (PubMed:25621951). Does not cleave efficiently polyubiquitin phosphorylated at \\\'Ser-65\\\' (PubMed:25527291). Acts as negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2 (By similarity).

Aliases: Deubiquitinating enzyme 30 antibody, FLJ40511 antibody, Ub-specific protease 30 antibody, Ubiquitin carboxyl terminal hydrolase 30 antibody, Ubiquitin carboxyl-terminal hydrolase 30 antibody, Ubiquitin specific peptidase 30 antibody, Ubiquitin specific processing protease 30 antibody, Ubiquitin thioesterase 30 antibody, Ubiquitin thiolesterase 30 antibody, Ubiquitin-specific-processing protease 30 antibody, UBP30_HUMAN antibody, usp30 antibody

UniProt: Q70CQ3